Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice

@article{Lakhan2015LocalAO,
  title={Local administration of AAV-DJ pseudoserotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice},
  author={Ram Lakhan and David J Prof Baylink and K H William Lau and Xiaolei Tang and Matilda H. C. Sheng and Charles H. Rundle and Xueyan Qin},
  journal={Gene Therapy},
  year={2015},
  volume={22},
  pages={721-728}
}
We have previously obtained compelling proof-of-principle evidence for COX2 gene therapy for fracture repair using integrating retroviral vectors. For this therapy to be suitable for patient uses, a suitable vector with high safety profile must be used. Accordingly, this study sought to evaluate the feasibility of AAV as the vector for this COX2 gene therapy, because AAV raises less safety issues than the retroviral vectors used previously. However, an appropriate AAV serotype is required to… CONTINUE READING
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SHOWING 1-10 OF 20 REFERENCES

Gene therapy for bone healing

CH Evans
  • Expert Rev Mol Med 2010;
  • 2010