Local activation of nonspecific defense against a respiratory model infection by application of interferon-gamma: comparison between rat alveolar and interstitial lung macrophages.

@article{Steinmller2000LocalAO,
  title={Local activation of nonspecific defense against a respiratory model infection by application of interferon-gamma: comparison between rat alveolar and interstitial lung macrophages.},
  author={C. Steinm{\"u}ller and G. Franke-Ullmann and M-L. Lohmann-Matthes and Andreas Emmend{\"o}rffer},
  journal={American journal of respiratory cell and molecular biology},
  year={2000},
  volume={22 4},
  pages={481-90}
}
Pulmonary macrophages play a crucial role in the defense of inhaled pathogens. We characterized functional properties of alveolar (AM) and interstitial (IM) macrophages from rats. AM exhibited a pronounced microbicidal capacity as shown by an elevated production of reactive oxygen intermediates (ROI), nitric oxide (NO), tumor necrosis factor (TNF)-alpha, and tumor cytotoxicity when compared with IM. In contrast, IM were superior to AM regarding mechanisms mainly involved in the induction and… CONTINUE READING