Local actions of angiotensin II: quantitative in vitro autoradiographic localization of angiotensin II receptor binding and angiotensin converting enzyme in target tissues.

@article{Chai1986LocalAO,
  title={Local actions of angiotensin II: quantitative in vitro autoradiographic localization of angiotensin II receptor binding and angiotensin converting enzyme in target tissues.},
  author={S. Y. Chai and Andrew M Allen and William Robert Adam and Frederick A O Mendelsohn},
  journal={Journal of cardiovascular pharmacology},
  year={1986},
  volume={8 Suppl 10},
  pages={S35-9}
}
In order to gain insight into the local actions of angiotensin II (ANG II) we have determined the distribution of a component of the effector system for the peptide, the ANG II receptor, and that of an enzyme-catalysing ANG II formation, angiotensin converting enzyme (ACE), by in vitro autoradiography in several target tissues. The superagonist ANG II analog, 125I[Sar1]ANG II, or the antagonist analog, 125I[Sar1,Ile8]ANG II, were used as specific radioligands for ANG II receptors. A derivative… CONTINUE READING
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