Local action of long-range repressors in the Drosophila embryo.

  title={Local action of long-range repressors in the Drosophila embryo.},
  author={Yutaka Nibu and Huan Zhang and Michael Levine},
  journal={The EMBO journal},
  volume={20 9},
Previous studies have identified two corepressors in the early Drosophila embryo: Groucho and dCTBP: Both proteins are recruited to the DNA template by interacting with short peptide motifs conserved in a variety of sequence-specific transcriptional repressors. Once bound to DNA, Groucho appears to mediate long-range repression, while dCtBP directs short-range repression. The short-range Krüppel repressor was converted into a long-range repressor by replacing the dCtBP interaction motif… CONTINUE READING