Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study

@article{CanoCebrin2003LocalAM,
  title={Local acamprosate modulates dopamine release in the rat nucleus accumbens through NMDA receptors: an in vivo microdialysis study},
  author={Mar{\'i}a Jos{\'e} Cano-Cebri{\'a}n and Teodoro Zornoza-Sabina and Consuelo Guerri and Ana Polache and Luis M. Granero},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2003},
  volume={367},
  pages={119-125}
}
The effects of acamprosate on the in vivo dopamine extracellular levels in the nucleus accumbens and the involvement of N-methyl-D-aspartate (NMDA) receptors in these effects were investigated. Microdialysis in freely moving rats was used to assess dopamine levels before and during simultaneous perfusion of acamprosate and/or different agonists or antagonists of NMDA receptors. Perfusion with acamprosate at concentrations of 0.5 and 5 mM provoked a concentration-dependent increase in… CONTINUE READING
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