Local Weighting Schemes for Protein Multiple Sequence Alignment

  title={Local Weighting Schemes for Protein Multiple Sequence Alignment},
  author={Jaap Heringa},
  journal={Computers & chemistry},
  volume={26 5},
This paper describes three weighting schemes for improving the accuracy of progressive multiple sequence alignment methods: (1) global profile pre-processing, to capture for each sequence information about other sequences in a profile before the actual multiple alignment takes place; (2) local pre-processing; which incorporates a new protocol to only use non-overlapping local sequence regions to construct the pre-processed profiles; and (3) local-global alignment, a weighting scheme based on… CONTINUE READING


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