Local Targeted Therapy of Liver Metastasis from Colon Cancer by Galactosylated Liposome Encapsulated with Doxorubicin

@inproceedings{Zhao2013LocalTT,
  title={Local Targeted Therapy of Liver Metastasis from Colon Cancer by Galactosylated Liposome Encapsulated with Doxorubicin},
  author={Chen Zhao and Qiang Feng and Zengpei Dou and Wei Yuan and Chenguang Sui and Xinghua Zhang and Guimin Xia and Hongfang Sun and Jie Ma},
  booktitle={PloS one},
  year={2013}
}
Since regional drug administration enables to maintain a high drug concentration within tumors, we compared the plasma concentration and biodistribution of doxorubicin (Dox) from drug-loaded conventional liposomes by local or systemic administration. The results demonstrated that drug concentration was substantially improved in liver as well as a decrease in blood and other organs by spleen injection mimicking portal vein perfusion (regional administration). To further investigate the targeted… CONTINUE READING

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