Local Rules Modeling of Nucleation-Limited Virus Capsid AssemblyMIT-LCS-TM-584

@inproceedings{Schwartz1998LocalRM,
  title={Local Rules Modeling of Nucleation-Limited Virus Capsid AssemblyMIT-LCS-TM-584},
  author={Russell Schwartz and Peter E. Prevelige and Bonnie Berger},
  year={1998}
}
We describe an application of computer modeling to the study of the kinetics of virus capsid (protein shell) assembly. We examine two proposed models of the source of nucleation-limited growth, an observed growth pattern in which initiation of new capsids occurs signi cantly more slowly than subunit addition onto initiated capsids. We apply an abstract computer model of capsid assembly, based on the principle of local rules, to support a theoretical argument for favoring a two-conformation… CONTINUE READING

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