Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating

@article{Merlini2016LocalPR,
  title={Local Pheromone Release from Dynamic Polarity Sites Underlies Cell-Cell Pairing during Yeast Mating},
  author={Laura Merlini and Bita Khalili and Felipe O Bendez{\'u} and Daniel A Hurwitz and Vincent Vincenzetti and Dimitrios Vavylonis and Sophie G. Martin},
  journal={Current Biology},
  year={2016},
  volume={26},
  pages={1117-1125}
}
Cell pairing is central for many processes, including immune defense, neuronal connection, hyphal fusion, and sexual reproduction. How does a cell orient toward a partner, especially when faced with multiple choices? Fission yeast Schizosaccharomyces pombe P and M cells, which respectively express P and M factor pheromones [1, 2], pair during the mating process induced by nitrogen starvation. Engagement of pheromone receptors Map3 and Mam2 [3, 4] with their cognate pheromone ligands leads to… CONTINUE READING
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