Local PCA Shows How the Effect of Population Structure Differs Along the Genome.

@article{Li2019LocalPS,
  title={Local PCA Shows How the Effect of Population Structure Differs Along the Genome.},
  author={Han Li and Peter L. Ralph},
  journal={Genetics},
  year={2019},
  volume={211 1},
  pages={
          289-304
        }
}
Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-specific genealogical trees, which can be strongly affected on intermediate genomic scales by linked selection and other factors. We show how to use local PCA to describe this… CONTINUE READING
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