Corpus ID: 91566002

Local Overexpression of Toll-Like Receptors at the Vessel Wall Induces Atherosclerotic Lesion Formation

@inproceedings{MasakazuShinohara2007LocalOO,
  title={Local Overexpression of Toll-Like Receptors at the Vessel Wall Induces Atherosclerotic Lesion Formation},
  author={MasakazuShinohara and Ken-ichiHirata and TomoyaYamashita and TomofumiTakaya and NaotoSasaki and RioShiraki and TomomiUeyama and NoriakiEmoto and NobutakaInoue and MitsuhiroYokoyama and SeinosukeKawashima},
  year={2007}
}
Objective— Atherosclerosis is now considered as a chronic inflammatory disease, and inflammation is closely related to immune systems, which consist of innate-immunity and adaptive-immunity. Recently, toll-like receptors (TLRs) have been identified as key components of innate-immunity. We examined the role of local expressions of TLRs at the vessel wall in atherosclerosis. Methods and Results— We transfected cDNA encoding human TLR2 and TLR4 into the carotid arterial vessel wall of rabbits fed… Expand
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