Corpus ID: 91994058

Local Overexpression of Monocyte Chemoattractant Protein-1 at Vessel Wall Induces Infiltration of Macrophages and Formation of Atherosclerotic Lesion

@article{MasayukiNamiki2002LocalOO,
  title={Local Overexpression of Monocyte Chemoattractant Protein-1 at Vessel Wall Induces Infiltration of Macrophages and Formation of Atherosclerotic Lesion},
  author={MasayukiNamiki and SeinosukeKawashima and TomoyaYamashita and Masanoriozaki and TetsuakiHirase and TatsuroIshida and NobutakaInoue and Ken-ichiHirata and AkihiroMatsukawa and RyuichiMorishita and YasufumiKaneda and MitsuhiroYokoyama},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2002}
}
Monocyte/macrophage infiltration to the arterial wall is an initial step in atherosclerosis, and monocyte chemoattractant protein-1 (MCP-1) is thought to play a central role in the recruitment of these cells. In the present study, we examined the role of local expression of MCP-1 at the vessel wall in the initiation and development of atherosclerosis. We transfected the cDNA encoding rat MCP-1 into the vessel wall of the rabbit carotid artery with the use of the hemagglutinating virus of Japan… Expand
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