Local Membrane Deformations Activate Ca2+-Dependent K+ and Anionic Currents in Intact Human Red Blood Cells

@inproceedings{Dyrda2010LocalMD,
  title={Local Membrane Deformations Activate Ca2+-Dependent K+ and Anionic Currents in Intact Human Red Blood Cells},
  author={Agnieszka Dyrda and Urszula Cytlak and Anna Ciuraszkiewicz and Agnieszka P Lipinska and Anne Cueff and Guillaume Bouyer and St{\'e}phane Eg{\'e}e and Poul Bennekou and Virgilio L. Lew and Serge L Y Thomas},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the cell's diameter. The shear stress induced by such flow, as well as the local membrane deformations generated in certain pathological conditions, such as sickle cell anemia, have been shown to increase membrane permeability, based largely on… CONTINUE READING

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