Local Low-Dose Lovastatin Delivery Improves the Bone-Healing Defect Caused by Nf1 Loss of Function in Osteoblasts

@inproceedings{Wang2010LocalLL,
  title={Local Low-Dose Lovastatin Delivery Improves the Bone-Healing Defect Caused by Nf1 Loss of Function in Osteoblasts},
  author={Weixi Wang and Jeffry S Nyman and Heather E Moss and Gloria Patricia Arango Guti{\'e}rrez and Gregory Robert Mundy and Xiangli Yang and Florent Elefteriou},
  booktitle={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2010}
}
Postfracture tibial nonunion (pseudoarthrosis) leads to lifelong disability in patients with neurofibromatosis type I (NF1), a disorder caused by mutations in the NF1 gene. To determine the contribution of NF1 in bone healing, we assessed bone healing in the Nf1(ob) (-/-) conditional mouse model lacking Nf1 specifically in osteoblasts. A closed distal tibia fracture protocol and a longitudinal study design were used. During the 21- to 28-day postfracture period, callus volume, as expected… CONTINUE READING
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