Local L-arginine delivery after balloon angioplasty reduces monocyte binding and induces apoptosis.

@article{Niebauer1999LocalLD,
  title={Local L-arginine delivery after balloon angioplasty reduces monocyte binding and induces apoptosis.},
  author={Josef Niebauer and Severin Paul Schwarzacher and Motoya Hayase and Bing-yin Wang and Robert S. Kernoff and John P Cooke and Alan Yeung},
  journal={Circulation},
  year={1999},
  volume={100 17},
  pages={1830-5}
}
BACKGROUND Local administration of L-arginine after balloon angioplasty has been shown to enhance NO generation and inhibit lesion formation. In this study, we assessed the mechanisms by which local delivery of L-arginine inhibits lesion formation. METHODS AND RESULTS New Zealand White rabbits (n=56) were fed a 1% cholesterol diet. After 1 week, both iliac arteries were balloon-denuded, and a local drug delivery catheter was introduced into both iliac arteries to deliver either L-arginine… CONTINUE READING

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