Local Inflammation, Dissemination and Coalescence of Lesions Are Key for the Progression toward Active Tuberculosis: The Bubble Model

@inproceedings{Prats2016LocalID,
  title={Local Inflammation, Dissemination and Coalescence of Lesions Are Key for the Progression toward Active Tuberculosis: The Bubble Model},
  author={Clara Prats and Cristina Vilaplana and Joaquim Valls and Elena Marzo and P E Cardona and Daniel L{\'o}pez},
  booktitle={Front. Microbiol.},
  year={2016}
}
The evolution of a tuberculosis (TB) infection toward active disease is driven by a combination of factors mostly related to the host response. The equilibrium between control of the bacillary load and the pathology generated is crucial as regards preventing the growth and proliferation of TB lesions. In addition, some experimental evidence suggests an important role of both local endogenous reinfection and the coalescence of neighboring lesions. Herein we propose a mathematical model that… CONTINUE READING
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