• Corpus ID: 248496562

Local Immunodeficiency: Transformation of Viruses' Functions

@inproceedings{Bunimovich2022LocalIT,
  title={Local Immunodeficiency: Transformation of Viruses' Functions},
  author={Leonid A. Bunimovich and Athulya Ram},
  year={2022}
}
We analyze three aspects of the phenomenon of local immunodeficiency. In all cases only a stable (i.e. observable) state of local immunodeficiency is considered. At first, we show that the appearance of a new virus may result in a change in the roles played by previously existed viruses in the in-host cross-immunoreactivity network. Particularly a persistent virus may become neutral and vice versa. Then we study what happens if two cross-immunoreactivity networks with stable local immunodeficiency… 

Figures from this paper

References

SHOWING 1-10 OF 19 REFERENCES

Local Immunodeficiency: Role of Neutral Viruses

It is shown that, even in the absence of altruistic viruses, neutral viruses can support the existence of persistent viruses and thus local immunodeficiency, and presents an absolutely minimal cross-immunoreactivity network where a stable and robust state of local immunODeficiency can be maintained.

Local immunodeficiency: Minimal networks and stability.

The evolutionary dynamics of HIV-1 quasispecies and the development of immunodeficiency disease.

A theory to explain the development of immunodeficiency disease after a long and variable incubation period of infection with HIV-1 is presented, which reveals that an increasing number of antigenically distinct viral strains may overwhelm the immune system of the host.

VirusesOriginal Antigenic Sin Responses to Influenza

It is shown that sequential infection of mice with two live influenza virus strains leads to almost exclusive Ab responses to the first viral strain, suggesting that original antigenic sin could be a potential strategy by which variant in﷽uenza viruses subvert the immune system.

Hepatitis C virus dynamics and pathology: the role of CTL and antibody responses.

  • D. Wodarz
  • Biology
    The Journal of general virology
  • 2003
The role of CTL and antibody responses in hepatitis C virus (HCV) dynamics and pathology is investigated and the relative balance of the immune response can be a decisive factor that determines whether patients are asymptomatic or whether pathology is observed.

Social evolution of innate immunity evasion in a virus

It is demonstrated that viral escape from interferon (IFN)-based innate immunity is a social process in which IFN-stimulating viruses determine the fitness of neighbouring viruses, and that IFN shutdown is costly because it reduces short-term viral progeny production, thus fulfilling the definition of an altruistic trait.

Antigenic diversity thresholds and the development of AIDS.

A mathematical model of the dynamic interaction between viral diversity and the human immune system suggests the existence of an antigen diversity threshold, below which the immune system is able to regulate viral population growth but above which the virus population induces the collapse of the CD4+ lymphocyte population.

Antigenic cooperation among intrahost HCV variants organized into a complex network of cross-immunoreactivity

It is shown that hepatitis C virus (HCV) genetic heterogeneity facilitates a stable state of immune adaptation rather than perpetuates an arms race, and a mathematical model that considers variation in breadth of immunoreactivity among antibodies and antigens and the contribution of immune memory to humoral response against HCV is developed.

Understanding Original Antigenic Sin in Influenza with a Dynamical System

A dynamical system model of the mechanism of original antigenic sin in influenza is developed and how a competition between different types of B cells compromises the overall effect of immune response is described.

Mathematical biology of HIV infections: antigenic variation and diversity threshold.