Local Gene Expression Changes after UV-Irradiation of Human Skin

@inproceedings{Weinkauf2012LocalGE,
  title={Local Gene Expression Changes after UV-Irradiation of Human Skin},
  author={Benjamin Weinkauf and Roman R Rukwied and Hans Quiding and Leif Dahllund and Patrick Johansson and Martin Schmelz},
  booktitle={PloS one},
  year={2012}
}
UV-irradiation is a well-known translational pain model inducing local inflammation and primary hyperalgesia. The mediators and receptor proteins specifically contributing to mechanical or heat hyperalgesia are still unclear. Therefore, we irradiated buttock skin of humans (n = 16) with 5-fold MED of UV-C and assessed the time course of hyperalgesia and axon reflex erythema. In parallel, we took skin biopsies at 3, 6 and 24 h after UVC irradiation and assessed gene expression levels (RT-PCR… CONTINUE READING
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