Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection

@inproceedings{Cheng2015LocalDO,
  title={Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection},
  author={C. Cheng and Chi-Te Lin and Meng-Jen Lee and May-Jywan Tsai and Wen-Hung Huang and Ming-Chao Huang and Yi-lo Lin and Ching-jung Chen and Wen-Cheng Huang and Henrich Cheng and Simone Di Giovanni},
  booktitle={PloS one},
  year={2015}
}
Chondroitin sulfate proteoglycans (CSPGs) are glial scar-associated molecules considered axonal regeneration inhibitors and can be digested by chondroitinase ABC (ChABC) to promote axonal regeneration after spinal cord injury (SCI). We previously demonstrated that intrathecal delivery of low-dose ChABC (1 U) in the acute stage of SCI promoted axonal regrowth and functional recovery. In this study, high-dose ChABC (50 U) introduced via intrathecal delivery induced subarachnoid hemorrhage and… CONTINUE READING
2
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Animal models of axon regeneration after spinal cord injury

DH Lee, JK Lee
  • Neuroscience bulletin
  • 2013
VIEW 3 EXCERPTS