Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells.

@article{Tartier2003LocalDD,
  title={Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells.},
  author={Laurence Tartier and Catherine Spenlehauer and Heidi C Newman and Melvyn Folkard and Kevin M Prise and Barry D Michael and Josiane M{\'e}nissier-de Murcia and Gilbert de Murcia},
  journal={Mutagenesis},
  year={2003},
  volume={18 5},
  pages={411-6}
}
Cellular recovery from ionizing radiation (IR)-induced damage involves poly(ADP-ribose) polymerase (PARP-1 and PARP-2) activity, resulting in the induction of a signalling network responsible for the maintenance of genomic integrity. In the present work, a charged particle microbeam delivering 3.2 MeV protons from a Van de Graaff accelerator has been used to locally irradiate mammalian cells. We show the immediate response of PARPs to local irradiation, concomitant with the recruitment of ATM… CONTINUE READING

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