Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut

@inproceedings{Scopelliti2014LocalCO,
  title={Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut},
  author={Alessandro Scopelliti and Julia B. Cordero and Fengqiu Diao and Karen Strathdee and Benjamin H White and Owen J Sansom and Marcos Vidal},
  booktitle={Current Biology},
  year={2014}
}
BACKGROUND Enteroendocrine cells populate gastrointestinal tissues and are known to translate local cues into systemic responses through the release of hormones into the bloodstream. RESULTS Here we report a novel function of enteroendocrine cells acting as local regulators of intestinal stem cell (ISC) proliferation through modulation of the mesenchymal stem cell niche in the Drosophila midgut. This paracrine signaling acts to constrain ISC proliferation within the epithelial compartment… CONTINUE READING
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The digestive tract of Drosophila melanogaster

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