Local Control Models of Cardiac Excitation–Contraction Coupling

  title={Local Control Models of Cardiac Excitation–Contraction Coupling  },
  author={Michael D. Stern and Long-sheng Song and Heping Cheng and James S.K. Sham and Huang Tian Yang and Kenneth R. Boheler and Eduardo R{\'i}os},
  journal={The Journal of General Physiology},
  pages={469 - 489}
In cardiac muscle, release of activator calcium from the sarcoplasmic reticulum occurs by calcium- induced calcium release through ryanodine receptors (RyRs), which are clustered in a dense, regular, two-dimensional lattice array at the diad junction. We simulated numerically the stochastic dynamics of RyRs and L-type sarcolemmal calcium channels interacting via calcium nano-domains in the junctional cleft. Four putative RyR gating schemes based on single-channel measurements in lipid bilayers… CONTINUE READING
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