Local Ca2+ Release from Internal Stores Controls Exocytosis in Pituitary Gonadotrophs

@article{Tse1997LocalCR,
  title={Local Ca2+ Release from Internal Stores Controls Exocytosis in Pituitary Gonadotrophs},
  author={Frederick W. Tse and Amy Tse and Bertil Hille and H. Horstmann and Wolfhard Almers},
  journal={Neuron},
  year={1997},
  volume={18},
  pages={121-132}
}
Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by other means. Strong exocytosis was then seen only at higher [Ca2+]i (half-maximal at 16 microM). Parallel second messengers did not contribute to GnRH-induced exocytosis, because… CONTINUE READING
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