Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans

@article{Chugani2001LocalBF,
  title={Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans},
  author={Harry T. Chugani and Michael E. Behen and Otto Muzik and Csaba Juh{\'a}sz and Ferenc Nagy and Diane C. Chugani},
  journal={NeuroImage},
  year={2001},
  volume={14},
  pages={1290-1301}
}
Early global deprivation of institutionalized children may result in persistent specific cognitive and behavioral deficits. In order to examine brain dysfunction underlying these deficits, we have applied positron emission tomography using 2-deoxy-2-[(18)F]fluoro-D-glucose in 10 children (6 males, 4 females, mean age 8.8 years) adopted from Romanian orphanages. Using statistical parametric mapping (SPM), the pattern of brain glucose metabolism in the orphans was compared to the patterns… 

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