Local Anesthetics Induce Apoptosis in Human Breast Tumor Cells

  title={Local Anesthetics Induce Apoptosis in Human Breast Tumor Cells},
  author={Yuan-Ching Chang and Chien-Liang Liu and Ming‐Jen Chen and Y W Hsu and Shanmei Chen and Chi-Hsin Lin and Chin-Man Chen and Feng Yang and Meng Hu},
  journal={Anesthesia \& Analgesia},
BACKGROUND:Previous studies have shown that local anesthetics may induce apoptosis in some cell types. In this study, we investigated the apoptotic effects of local anesthetics in human breast tumor cells. METHODS:Human breast cancer (MCF-7) and mammary epithelial (MCF-10A) cell lines were treated with lidocaine and/or bupivacaine. Cell viability, DNA fragmentation, and annexin V immunofluorescence staining were assessed. The effects on apoptosis-related protein expression were investigated by… 

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