Lobular neoplasia.

@article{King2014LobularN,
  title={Lobular neoplasia.},
  author={Tari A King and Jorge S Reis-Filho},
  journal={Surgical oncology clinics of North America},
  year={2014},
  volume={23 3},
  pages={
          487-503
        }
}
Lobular neoplasia (LN) is characterized by a dysfunctional E-cadherin-catenin axis, and loss of E-cadherin plays a causative role in the typical morphology of LN cells. LN is both a nonobligate precursor and a risk indicator of invasive breast cancer, and in particular, of invasive lobular carcinoma. Despite the evidence supporting the precursor role of LN, its impact on clinical management has been a matter of controversy, and conservative management remains the mainstay of treatment. In this… CONTINUE READING

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Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma.

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