Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice

@article{Sajja2011LobelineAC,
  title={Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice},
  author={Ravi K Sajja and Shafiqur Rahman},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2011},
  volume={35},
  pages={257-264}
}
  • Ravi K Sajja, S. Rahman
  • Published 15 January 2011
  • Chemistry, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Brain nicotinic acetylcholine receptors (nAChRs) have been implicated in the rewarding effects of ethanol and other drugs of abuse. The present study examined the effects of two important nicotinic ligands that target nAChRs, on ethanol consumption in drinking-in-the-dark or continuous access two-bottle choice drinking procedures in C57BL/6J mice. Nicotinic alkaloids such as lobeline or cytisine were administered via subcutaneous (s.c.) injections about 25 min before offering ethanol solutions… Expand
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Results indicate that nAChRmediated signaling is critical in regulating nicotine-induced ethanol drinking behaviors, and indicates that neuronal nicotinic acetylcholine receptors in the midbrain dopamine system are common targets for the neurobehavioral interactions between alcohol and nicotine. Expand
Nicotinic receptor partial agonists modulate alcohol deprivation effect in C57BL/6J mice
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Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice.
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Antidepressant-like effects of lobeline in mice: Behavioral, neurochemical, and neuroendocrine evidence
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  • Medicine, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2013
TLDR
Overall, the present study indicates that lobeline produces antidepressant-like effects by targeting brain nAChRs and/or neuroendocrine and brain noradrenergic systems. Expand
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References

SHOWING 1-10 OF 53 REFERENCES
Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.
TLDR
Findings provide further evidence that activity at the nAChR influences ethanol intake and is a promising target for pharmacotherapy development for the treatment of alcohol dependence and relapse. Expand
Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment.
TLDR
The present results further implicate central nicotinic receptors in the molecular events mediating the reinforcing properties of ethanol, and suggest that subchronic nicotine enhances the responsiveness of mesolimbic dopamine neurons both to nicotine and to ethanol. Expand
Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice
TLDR
Results showed that lobeline significantly reduced alcohol consumption and alcohol preference during the repeated (recurring and continuous) administration phases, while total fluid consumption remained unchanged, providing support that nicotinic receptor based drugs may be useful as potential treatments for alcoholism. Expand
Acute effects of Naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice
TLDR
The DID model demonstrates predictive validity and both opioid and dopamine signaling are involved in ethanol drinking to intoxication, different physiological pathways mediate high ethanol drinking as compared to water or sugar water drinking in DID. Expand
Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice
TLDR
Neuronal nAChRs are involved in ethanol consumption in the DID paradigm and the effects of mecamylamine, nicotine, and cytisine on ethanol intake appear to be specific because they do not reduce sucrose drinking. Expand
Nicotinic Ligands Modulate Ethanol-Induced Dopamine Function in Mice
TLDR
Evidence is provided that lobeline and cytisine modulate ethanol-induced DA function by targeting nicotinic acetylcholine receptors in the ventral striatum, a reward-relevant brain region implicated in ethanol dependence. Expand
Lobeline attenuates d-methamphetamine self-administration in rats.
TLDR
It is suggested that lobeline produces a nonspecific rate suppressant effect following acute administration, to which tolerance develops following repeated administration, and repeated administration of lobeline specifically decreases responding for d-methamphetamine in a noncompetitive manner. Expand
Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice
TLDR
Evidence is provided that α7 nAChRs are involved in ethanol consumption and supports the idea that pharmacological manipulation of nA ChRs reduces ethanol intake, and there may be functional redundancy in the nicotinic control of alcohol drinking. Expand
Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking
Alcohol dependence is a disease that impacts millions of individuals worldwide. There has been some progress with pharmacotherapy for alcohol-dependent individuals; however, there remains a criticalExpand
The influence of lobeline on nucleus accumbens dopamine and locomotor responses to nicotine in nicotine‐pretreated rats
TLDR
The results suggest that lobeline is a short‐acting antagonist of the nicotinic AChRs which mediate the effects of nicotine on mesolimbic dopamine activity and locomotor stimulation. Expand
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