Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus.

@article{Singh2001LobespecificII,
  title={Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus.},
  author={R. Singh and C. Leuratti and S. Josyula and M. Sipowicz and B. Diwan and K. Kasprzak and H. Schut and L. Marnett and L. Anderson and D. Shuker},
  journal={Carcinogenesis},
  year={2001},
  volume={22 8},
  pages={
          1281-7
        }
}
Helicobacter hepaticus infection is associated with chronic hepatitis and the development of liver tumours in mice. The underlying mechanism of this liver carcinogenesis is not clear but the oxidative stress associated with H. hepaticus infection may result in induction of lipid peroxidation and the generation of malondialdehyde. Malondialdehyde can react with deoxyguanosine in DNA resulting in the formation of the cyclic pyrimidopurinone N-1,N(2) malondialdehyde-deoxyguanosine (M1dG) adduct… Expand
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