Loading of Arabidopsis centromeric histone CENH3 occurs mainly during G2 and requires the presence of the histone fold domain.

@article{Lermontova2006LoadingOA,
  title={Loading of Arabidopsis centromeric histone CENH3 occurs mainly during G2 and requires the presence of the histone fold domain.},
  author={Inna Lermontova and Veit Schubert and Joerg Fuchs and Sabina Klatte and Jir{\'i} Macas and Ingo Schubert},
  journal={The Plant cell},
  year={2006},
  volume={18 10},
  pages={2443-51}
}
The centromeric histone H3 (CENH3) substitutes histone H3 within the nucleosomes of active centromeres in all eukaryotes. CENH3 deposition at centromeres is needed to assemble the kinetochore, a complex of conserved proteins responsible for correct chromosome segregation during nuclear division. Histones of regular nucleosomes are loaded during replication in S phase, while CENH3 deposition deviates from this pattern in yeast, human, and Drosophila melanogaster cells. Little is known about when… CONTINUE READING
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Centromere targeting elementwithinthehistonefolddomainofCid

  • D. Vermaak, H. S. Hayden, S. Henikoff
  • Mol . Cell . Biol .
  • 2002
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