Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress.

@article{Paschen2003LoadingNW,
  title={Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress.},
  author={Wulf Paschen and Svenja Hotop and Christoph Aufenberg},
  journal={Cell calcium},
  year={2003},
  volume={33 2},
  pages={83-9}
}
Loading cells with the calcium chelator BAPTA-AM is an analytical tool which has been used to suppress a rise in cytoplasmic calcium activity under various experimental conditions and thus, to evaluate the role of elevated cytoplasmic calcium levels in the process under investigation. BAPTA-AM may, however, not only have an isolated effect on cytoplasmic processes but also on functions of other subcellular compartments such as the endoplasmic reticulum (ER). Under conditions associated with ER… CONTINUE READING