Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.

@article{Jacquemet2008LoadingEO,
  title={Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.},
  author={Vincent Jacquemet and Craig S. Henriquez},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 5},
  pages={H2040-52}
}
The numerous nonmyocytes present within the myocardium may establish electrical connections with myocytes through gap junctions, formed naturally or as a result of a cell therapy. The strength of the coupling and its potential impact on action potential characteristics and conduction are not well understood. This study used computer simulation to investigate the load-induced electrophysiological consequences of the coupling of myocytes with fibroblasts, where the fibroblast resting potential… CONTINUE READING
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