Loading dose of vancomycin in critically ill patients: 15 mg/kg is a better choice than 500 mg.

@article{Mohammedi2006LoadingDO,
  title={Loading dose of vancomycin in critically ill patients: 15 mg/kg is a better choice than 500 mg.},
  author={Isma{\"e}l Mohammedi and Elodie Descloux and Laurent Argaud and Julie Le Scanff and Dominique Robert},
  journal={International journal of antimicrobial agents},
  year={2006},
  volume={27 3},
  pages={259-62}
}
Delays in antimicrobial therapy in high-risk patients with infection may have deleterious effects on clinical outcomes. Therefore, appropriate treatment must be initiated promptly. The objective of this prospective study was to determine the better loading dose of vancomycin in critically ill patients with suspected Gram-positive infections. Two groups of patients were studied successively: Group A, loading dose of 500 mg; and Group B, loading dose of 15 mg/kg. The mean post-loading dose serum… CONTINUE READING

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