Loading and release of a phospholipid from contact lenses.

  title={Loading and release of a phospholipid from contact lenses.},
  author={William G. Pitt and Daniel Jack and Yibei Zhao and Jared L Nelson and John D Pruitt},
  journal={Optometry and vision science : official publication of the American Academy of Optometry},
  volume={88 4},
PURPOSE Dry eye syndrome has been associated with the lack of phospholipids in the tear film, leading to disruption of the tear film and subsequent irritation. This study explores the feasibility of loading a phospholipid into contact lenses for controlled release to the eye. METHODS Silicone hydrogel contact lenses were loaded with 33 μg of radio-labeled 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) from a solution of n-propanol. The loaded lenses were soaked at 35°C in either water or… CONTINUE READING