Loaded wheel running and muscle adaptation in the mouse.

@article{Konhilas2005LoadedWR,
  title={Loaded wheel running and muscle adaptation in the mouse.},
  author={JohnP. Konhilas and Ulrika Widegren and Darrel L. Allen and A-L. Paul and Allison Shea Cleary and L. A. Leinwand},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 1},
  pages={
          H455-65
        }
}
Voluntary cage wheel exercise has been used extensively to determine the physiological adaptation of cardiac and skeletal muscle in mice. In this study, we tested the effect of different loading conditions on voluntary cage wheel performance and muscle adaptation. Male C57Bl/6 mice were exposed to a cage wheel with no-resistance (NR), low-resistance (LR), or high-resistance (HR) loads for 7 wk. Power output was elevated (3-fold) under increased loading (LR and HR) conditions compared with… CONTINUE READING

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Sex modifies exercise and cardiac adaptation in the mouse

  • JP Konhilas, AH Maass, +4 authors LA. Leinwand
  • Am J Physiol Heart Circ Physiol 287:
  • 2004
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