Load responsiveness of protein synthesis in adult mammalian myocardium: role of cardiac deformation linked to sodium influx.

Abstract

Exposure of adult mammalian myocardium to increased hemodynamic loads augments cardiac protein synthesis, ultimately leading to hypertrophy of the affected chamber. This established relationship between loading conditions and protein synthesis was examined in terms of two questions. First, is there a basic difference between the anabolic effect of a passive… (More)

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@article{Kent1989LoadRO, title={Load responsiveness of protein synthesis in adult mammalian myocardium: role of cardiac deformation linked to sodium influx.}, author={Robert L. Kent and J. Kenneth Hoober and George Cooper}, journal={Circulation research}, year={1989}, volume={64 1}, pages={74-85} }