LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression

  title={LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression},
  author={Xue Chen and Chao Jiang and Bing Qin and Guohua Liu and Jiangdong Ji and Xiantao Sun and Min Xu and Sijia Ding and Meidong Zhu and Guofu Huang and Biao Yan and Chen Zhao},
  journal={Cell Death \& Disease},
Long noncoding RNAs (lncRNAs) have important roles in various biological processes. Our previous work has revealed that dedifferentiation of retinal pigment epithelium (RPE) cells contributes to the pathology of age-related macular degeneration (AMD). Herein, we show roles of lncRNAs in RPE differentiation. We used microarray to identify lncRNA expression profiles in human induced pluripotent stem cells (hiPSCs) and hiPSC-derived RPE cells. A total of 217 differentially expressed lncRNAs along… 
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