LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression

@article{Chen2017LncRNAZP,
  title={LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression},
  author={Xue Chen and Chao Jiang and Bing Qin and Guohua Liu and Jiangdong Ji and Xiantao Sun and Min Xu and Sijia Ding and Meidong Zhu and Guofu Huang and Biao Yan and Chen Zhao},
  journal={Cell Death \& Disease},
  year={2017},
  volume={8}
}
Long noncoding RNAs (lncRNAs) have important roles in various biological processes. Our previous work has revealed that dedifferentiation of retinal pigment epithelium (RPE) cells contributes to the pathology of age-related macular degeneration (AMD). Herein, we show roles of lncRNAs in RPE differentiation. We used microarray to identify lncRNA expression profiles in human induced pluripotent stem cells (hiPSCs) and hiPSC-derived RPE cells. A total of 217 differentially expressed lncRNAs along… 
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References

SHOWING 1-10 OF 46 REFERENCES
MicroRNA-184 promotes differentiation of the retinal pigment epithelium by targeting the AKT2/mTOR signaling pathway
TLDR
The findings suggest that miR-184 insufficiency is involved in the pathogenesis of dry AMD because it promotes RPE differentiation via inhibiting the AKT2/mTOR signaling pathway.
Identification of Corneal Neovascularization–Related Long Noncoding RNAs Through Microarray Analysis
TLDR
This study provides a novel insight into CN pathogenesis and the intervention of dysregulated lncRNAs may become potential targets for the prevention and treatment of ocular vascular diseases.
Aberrant expression of long noncoding RNAs in early diabetic retinopathy.
PURPOSE Long noncoding RNAs (lncRNAs) are broadly classified as transcripts longer than 200 nucleotides. lncRNA-mediated biology has been implicated in a variety of cellular processes and human
Microphthalmia-associated Transcription Factor (MITF) Promotes Differentiation of Human Retinal Pigment Epithelium (RPE) by Regulating microRNAs-204/211 Expression*
TLDR
It is found that miR-204/211, the two most highly expressed miRNAs in the RPE, were significantly down-regulated in dedifferentiated hfRPE cells, and co-transfection of MITF siRNA with pre-miR- 204/211 rescued RPE phenotype.
The long noncoding RNA RNCR2 directs mouse retinal cell specification
TLDR
It is demonstrated that the lncRNA RNCR2 plays a critical role in regulating mammalian retinal cell fate specification, and a novel approach is presented for generating dominant-negative constructs of lncRNAs, which may be generally useful in the functional analysis of this class of molecules.
lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA.
TLDR
This study highlights the involvement of lNCRNA-MIAT in pathological angiogenesis and facilitates the development of lncRNA-directed diagnostics and therapeutics against neovascular diseases.
Identification and characterization of proliferative retinopathy-related long noncoding RNAs.
Long noncoding RNA associated-competing endogenous RNAs in gastric cancer
TLDR
Based on lncRNA microarray data of gastric cancer, bioinformatic algorithm miRcode and microRNA (miRNA) targets database TarBase, and data of six types of other cancer, results suggest that lncRNAs harbor MREs and play important roles in post-transcriptional regulation in cancer.
Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells.
TLDR
Evidence is provided that Taz and its coactivator, Tead1, regulate expression of the EMT transcription factor Zeb1 to control RPE cell proliferation and differentiation.
CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer
TLDR
The study elucidates that fine tuning of HULC expression is part of an auto-regulatory loop in which it’s inhibitory to expression and activity of miR-372 allows lncRNA up-regulated expression in liver cancer.
...
...