LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression

@article{Chen2017LncRNAZP,
  title={LncRNA ZNF503-AS1 promotes RPE differentiation by downregulating ZNF503 expression},
  author={Xue Chen and Chao Jiang and Bing Qin and Guohua Liu and Jiangdong Ji and Xiantao Sun and Min Xu and Sijia Ding and Meidong Zhu and Guofu Huang and Biao Yan and Chen Zhao},
  journal={Cell Death \& Disease},
  year={2017},
  volume={8}
}
Long noncoding RNAs (lncRNAs) have important roles in various biological processes. Our previous work has revealed that dedifferentiation of retinal pigment epithelium (RPE) cells contributes to the pathology of age-related macular degeneration (AMD). Herein, we show roles of lncRNAs in RPE differentiation. We used microarray to identify lncRNA expression profiles in human induced pluripotent stem cells (hiPSCs) and hiPSC-derived RPE cells. A total of 217 differentially expressed lncRNAs along… 
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33 Citations

LINC00167 Regulates RPE Differentiation by Targeting the miR-203a-3p/SOCS3 Axis
lncRNA MEG3, Acting as a ceRNA, Modulates RPE Differentiation Through the miR-7-5p/Pax6 Axis
TLDR
It is demonstrated that MEG3 exerts a protective role against AMD by maintaining RPE differentiation via miR-7-5p/Pax6 axis, suggesting a protective therapeutic target in AMD treatment.
c-Jun-mediated microRNA-302d-3p induces RPE dedifferentiation by targeting p21Waf1/Cip1
TLDR
In vitro study supported that miR-302d-3p induces RPE dedifferentiation typified by reduction of RPE characteristic markers, interrupts its phagocytosis, and promotes its migration, proliferation, and cell-cycle progression, and induces abnormal EC behavior by targeting p21Waf1/Cip1.
Altered Long Non-coding RNAs Involved in Immunological Regulation and Associated with Choroidal Neovascularization in Mice
TLDR
Dysregulated lncRNAs and their target genes might be promising therapeutic targets to suppress CNV in AMD and are involved in immunological regulation, suggesting that lnc RNAs may play a critical role in the pathogenesis of CNV.
Circular Noncoding RNA NR3C1 Acts as a miR-382-5p Sponge to Protect RPE Functions via Regulating PTEN/AKT/mTOR Signaling Pathway.
LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca2+ concentration via transcription factor GATA6
TLDR
ZNF503-AS1 can recruit transcription factor GATA6 to up-regulate SLC8A1 expression, thereby increasing the intracellular Ca 2+ concentration and repressing the proliferation, invasion and migration, and enhancing the apoptosis of bladder cancer cells.
ZNF503 accelerates aggressiveness of hepatocellular carcinoma cells by down-regulation of GATA3 expression and regulated by microRNA-495.
TLDR
Conclusively, the data revealed that ZNF503 promoted migration, invasion and EMT process through regulating GATA3 expression, which was regulated by miR-495, suggesting the potential therapeutic value for HCC.
Transcriptome Analyses of lncRNAs in A2E-Stressed Retinal Epithelial Cells Unveil Advanced Links between Metabolic Impairments Related to Oxidative Stress and Retinitis Pigmentosa
TLDR
Analyzed lncRNAs could be involved in several biochemical pathways related to compromised response to oxidative stress, carbohydrate and lipid metabolism impairment, melanin biosynthetic process alteration, deficiency in cellular response to amino acid starvation, unbalanced regulation of cofactor metabolic process, all leading to retinal cell death.
Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration
TLDR
Further works on lncRNAs in AMD are rational, and they should be enriched with mechanistic and clinical studies to validate conclusions obtained in high-throughput in vitro research.
Long noncoding RNA LINC00346 promotes glioma cell migration, invasion and proliferation by up‐regulating ROCK1
TLDR
A new regulatory network is revealed in glioma and potential therapeutic targets for this cancer are identified, showing that LINC00346 may function as a competing endogenous RNA of miR‐340‐5p, thereby de‐repressing ROCK1.
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