LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway.

@article{Xiao2016LncRNAUP,
  title={LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway.},
  author={C Xiao and C Wu and H z Hu},
  journal={European review for medical and pharmacological sciences},
  year={2016},
  volume={20 13},
  pages={2819-24}
}
  • C Xiao, C Wu, H z Hu
  • Published 2016 in
    European review for medical and pharmacological…
OBJECTIVE LncRNA UCA1 can promote invasion of breast cancer cells. However, the underlying mechanism is not quite clear. In this study, we investigated the regulative effect of UCA1 on the invasion capability of breast cancer cells and its association with the Wnt/β-catenin pathway. MATERIALS AND METHODS Human breast cancer cell line MDA-MB-231 cells were transfected for UCA1 knockdown using UCA1 si-RNA. Transwell assay was performed to assess cell invasion capability. Western blot analysis… CONTINUE READING