LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4.

@article{Xiao2017LncRNAMS,
  title={LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4.},
  author={Xiaoxiong Xiao and Tingwen Zhou and Shichao Guo and Chao Guo and Qiao Zhang and Nianguo Dong and Yongjun Wang},
  journal={International journal of cardiology},
  year={2017},
  volume={243},
  pages={
          404-412
        }
}
BACKGROUND Emerging evidences have indicated that long non-coding RNAs (lncRNAs) play vital roles in cardiovascular physiology and pathology. The lncRNA MALAT1, a highly abundant and conserved imprinted gene, has been implicated in many cardiovascular diseases. However, the function of MALAT1 in calcific aortic valve disease (CAVD) remains unknown. This study sought to document the function and underlying mechanism of MALAT1 in regulating CAVD. METHODS Protein level was determined by… CONTINUE READING
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