LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer.

@article{Wang2015LncRNAME,
  title={LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer.},
  author={Dejie Wang and Liya Ding and Liguo Wang and Yu Zhao and Zhifu Sun and Robert Jeffrey Karnes and Jun Zhang and Haojie Huang},
  journal={Oncotarget},
  year={2015},
  volume={6 38},
  pages={41045-55}
}
The Polycomb protein enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in advanced human prostate cancer (PCa), especially in lethal castration-resistant prostate cancer (CRPC). However, the signaling pathways that regulate EZH2 functions in PCa remain incompletely defined. Using EZH2 antibody-based RNA immunoprecipitation-coupled high throughput sequencing (RIP-seq), we demonstrated that EZH2 binds to MALAT1, a long non-coding RNA (lncRNA) that is overexpressed during PCa… CONTINUE READING
Highly Cited
This paper has 91 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

91 Citations

020402015201620172018
Citations per Year
Semantic Scholar estimates that this publication has 91 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…