LncRNA-Dependent Mechanisms of Androgen Receptor-regulated Gene Activation Programs

@inproceedings{Yang2013LncRNADependentMO,
  title={LncRNA-Dependent Mechanisms of Androgen Receptor-regulated Gene Activation Programs},
  author={Liuqing Yang and Chunru Lin and Chunyu Jin and Joy C. Yang and Bogdan Tanasa and Wenbo Li and Daria Merkurjev and Kenneth a. Ohgi and Da Meng and Jie Zhang and Christopher P Evans and Michael G. Rosenfeld},
  booktitle={Nature},
  year={2013}
}
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly understood. The androgen receptor regulates a large repertoire of genes central to the identity and behaviour of prostate cancer cells, and functions in a ligand-independent fashion in many prostate cancers when they become hormone refractory after… CONTINUE READING
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