LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p

@inproceedings{Bian2016LncRNAUCA1EC,
  title={LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p},
  author={Zehua Bian and Liugen Jin and Jiwei Zhang and Yuan M Yin and Chao Hui Quan and Yaling Hu and Yuyang Feng and Heyong Liu and Bojian Fei and Yong Xing Mao and Leyuan Zhou and Xiaowei Qi and Shenlin Huang and Dong Yong Hua and ChunGen Xing and Zhaohui Huang},
  booktitle={Scientific reports},
  year={2016}
}
Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in vivo functions and molecular mechanism of UCA1 in CRC remain unclear. Therefore, we investigated the detailed role and mechanism of UCA1 in CRC. We found that UCA1 was up-regulated in CRCs and negatively correlated with survival time in two CRC cohorts. Functional assays revealed the in vitro and in vivo growth… CONTINUE READING
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