LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

@inproceedings{Zhu2016LncBRMIY,
  title={LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells},
  author={Pingping Zhu and Yanying Wang and Jiayi Wu and Guanling Huang and Benyu Liu and Buqing Ye and Ying Du and Guangxia Gao and Yong Tian and Lei He and Zusen Fan},
  booktitle={Nature communications},
  year={2016}
}
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly expressed in liver CSCs and HCC tumours. LncBRM is required for the self-renewal maintenance of liver CSCs and tumour initiation. In liver CSCs, lncBRM associates with BRM to… CONTINUE READING
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