Lnc-ing ROR1–HER3 and Hippo signalling in metastasis

Abstract

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP… (More)
DOI: 10.1038/ncb3467

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.