Ln(III)-DOTAMGly complexes: a versatile series to assess the determinants of the efficacy of paramagnetic chemical exchange saturation transfer agents for magnetic resonance imaging applications.

@article{Terreno2004LnIIIDOTAMGlyCA,
  title={Ln(III)-DOTAMGly complexes: a versatile series to assess the determinants of the efficacy of paramagnetic chemical exchange saturation transfer agents for magnetic resonance imaging applications.},
  author={Enzo Terreno and Daniela Delli Castelli and Giancarlo Cravotto and Luciano Milone and Silvio Aime},
  journal={Investigative radiology},
  year={2004},
  volume={39 4},
  pages={235-43}
}
RATIONALE AND OBJECTIVES Paramagnetic Ln-DOTAMGly complexes (Ln not equal La, Lu, and Gd) are the prototypes of a novel class of contrast agents for magnetic resonance imaging based on chemical exchange saturation transfer (CEST). Their ability to reduce the water signal intensity depends on the interplay of several physico-chemical properties of the agent and instrumental parameters. This study aims to identify possible routes for their optimization METHODS Saturation transfer (ST) has been… CONTINUE READING