Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.

Abstract

Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human podocin gene NPHS2 cause familial or sporadic forms of renal disease owing to the disruption of filtration barrier integrity. The exclusive expression of NPHS2 in podocytes reflects its unique… (More)
DOI: 10.1681/ASN.2012080823

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