Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2

@inproceedings{Hoekstra2013Lmx1aEA,
  title={Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2},
  author={Elisa J. Hoekstra and Lars von Oerthel and Lars P. van der Heide and Willemieke M. Kouwenhoven and Jesse V Veenvliet and Iris Wever and Yongdong. Jin and Jeong Kyo Yoon and Annemarie J. A. van der Linden and Frank Holstege and Marian J A Groot Koerkamp and Marten P Smidt},
  booktitle={PloS one},
  year={2013}
}
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential for chick mdDA development, and for the efficient differentiation of ES-cells towards a dopaminergic phenotype. In this study, we aimed towards a more detailed understanding of the subtle phenotype in Lmx1a-deficient (dreher) mice, by means of gene… CONTINUE READING

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