Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.

@article{Lasek2011LmoGR,
  title={Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.},
  author={Amy W Lasek and Francesco Giorgetti and Karen H. Berger and Stacy Tayor and Ulrike Heberlein},
  journal={Alcoholism, clinical and experimental research},
  year={2011},
  volume={35 9},
  pages={1600-6}
}
BACKGROUND Previous work from our laboratory demonstrated a role for the Drosophila Lim-only (dLmo) gene in regulating behavioral responses to cocaine. Herein, we examined whether dLmo influences the flies' sensitivity to ethanol's sedating effects. We also investigated whether 1 of the mammalian homologs of dLmo, Lmo3, is involved in behavioral responses to ethanol in mice. METHODS To examine dLmo function in ethanol-induced sedation, mutant flies with reduced or increased dLmo expression… CONTINUE READING
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