Llama-derived single-domain intrabodies inhibit secretion of hepatitis B virions in mice.


UNLABELLED Hepatitis B virus (HBV) infections cause 500,000 to 700,000 deaths per year as a consequence of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Efficient and safe antivirals to treat chronically infected patients and consequently to prevent development of hepatocellular carcinoma are still awaited. We isolated five single-domain… (More)
DOI: 10.1002/hep.22609


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