Lixisenatide: First Global Approval

@article{Elkinson2013LixisenatideFG,
  title={Lixisenatide: First Global Approval},
  author={Shelley Elkinson and Gillian M. Keating},
  journal={Drugs},
  year={2013},
  volume={73},
  pages={383-391}
}
The selective once-daily prandial glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide (Lyxumia®) is under development with Sanofi for the treatment of type 2 diabetes mellitus. Lixisenatide belongs to a class of GLP-1 compounds designed to mimic the endogenous hormone GLP-1. Native GLP-1 stimulates insulin secretion in a glucose-dependent manner, as well as suppressing glucagon production and slowing gastric emptying. A once-daily subcutaneous formulation of lixisenatide has been… 
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Lixisenatide: A New Member of the Glucagon-Like Peptide 1 Receptor Agonist Class of Incretin Therapies
TLDR
This article provides a review of lixisenatide, a once-daily GLP-1 receptor agonist for the treatment of type 2 diabetes.
Lixisenatide: a guide to its use as add-on therapy in type 2 diabetes mellitus
TLDR
In clinical trials in this patient population, add-on therapy with once-daily subcutaneous lixisenatide improved glycaemic control, had beneficial effects on bodyweight and was generally well tolerated.
Lixisenatide as add-on therapy to basal insulin
TLDR
Lixisenatide exerts profound effects on postprandial glucose through established mechanisms of glucose-dependent insulin secretion and glucagon suppression in combination with delayed gastric emptying, making it a novel incretin agent for use in combinationWith optimally titrated basal insulin.
Neuroprotective effects of lixisenatide and liraglutide in the MPTP mouse model of Parkinson's disease.
TLDR
Both liraglutide and lixisenatide are superior to exendin-4, and both drugs show promise as a novel treatment of PD.
Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
TLDR
Both liraglutide and lixisenatide are superior to exendin-4, and both drugs show promise as a novel treatment of PD.
Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases.
TLDR
GLP-1 mimetics show great promise as a novel treatment for neurodegenerative conditions because of the substantial body of evidence that these mimetics have neuroprotective and anti-inflammatory effects.
AUTHOR COPY ONLY Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
TLDR
GLP-1 mimetics show great promise as a novel treatment for neurodegenerative conditions because of the substantial body of evidence that these mimetics have neuroprotective and anti-inflammatory effects.
Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease
TLDR
The results demonstrate that the GLP-1 receptor agonists liraglutide and lixisenatide show promise as potential drug treatments of AD.
Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon.
TLDR
A detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members of the glucagon family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon is provided.
The effect of liraglutide on endothelial function in patients with type 2 diabetes
TLDR
Liraglutide did not significantly impact endothelium-dependent vasodilation after 12 weeks; however, additional investigations looking at the effect of liragLutide on endothelial function in alternative vasculature and during the postprandial period are warranted.
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