Lixisenatide: First Global Approval

@article{Elkinson2013LixisenatideFG,
  title={Lixisenatide: First Global Approval},
  author={Shelley Elkinson and Gillian M. Keating},
  journal={Drugs},
  year={2013},
  volume={73},
  pages={383-391}
}
The selective once-daily prandial glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide (Lyxumia®) is under development with Sanofi for the treatment of type 2 diabetes mellitus. Lixisenatide belongs to a class of GLP-1 compounds designed to mimic the endogenous hormone GLP-1. Native GLP-1 stimulates insulin secretion in a glucose-dependent manner, as well as suppressing glucagon production and slowing gastric emptying. A once-daily subcutaneous formulation of lixisenatide has been… 
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TLDR
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TLDR
GLP-1 mimetics show great promise as a novel treatment for neurodegenerative conditions because of the substantial body of evidence that these mimetics have neuroprotective and anti-inflammatory effects.
AUTHOR COPY ONLY Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
TLDR
GLP-1 mimetics show great promise as a novel treatment for neurodegenerative conditions because of the substantial body of evidence that these mimetics have neuroprotective and anti-inflammatory effects.
Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease
TLDR
The results demonstrate that the GLP-1 receptor agonists liraglutide and lixisenatide show promise as potential drug treatments of AD.
Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon.
TLDR
A detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members of the glucagon family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon is provided.
The effect of liraglutide on endothelial function in patients with type 2 diabetes
TLDR
Liraglutide did not significantly impact endothelium-dependent vasodilation after 12 weeks; however, additional investigations looking at the effect of liragLutide on endothelial function in alternative vasculature and during the postprandial period are warranted.
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