Living with the enemy: a physiological role for the β-amyloid peptide

@article{Esteban2004LivingWT,
  title={Living with the enemy: a physiological role for the β-amyloid peptide},
  author={Jos{\'e} A Esteban},
  journal={Trends in Neurosciences},
  year={2004},
  volume={27},
  pages={1-3}
}
The Ab peptide, which is derived from the processing of the amyloid precursor protein APP, is the principal agent responsible for the pathogenesis of Alzheimer’s disease. In a recent study by Kamenetz et al., Ab is shown to mediate a physiological homeostatic mechanism that reduces excitatory transmission in response to neuronal activity. Failure of this autoregulatory feedback could lead to the neuropathology of Alzheimer’s disease.